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Benecol® with plant stanol ester – Clinically proven to lower cholesterol

Hypercholesterolemia can be effectively improved with dietary modifications. When guiding patients on a healthy, cholesterol-lowering diet and lifestyle, recommending the use of Plant stanol ester is encouraged by national and international guidelines1–14. Plant stanol ester is the active ingredient in all Benecol® products.

Benecol® is a pioneer in cholesterol-lowering foods. We want to support you in your work as a healthcare professional. This section provides information and materials to help you in your work with hypercholesterolemia patients.

Reducing LDL Cholesterol: the unmet need

Learn more about how plant stanols work

Plant stanols: Clinically proven in 80+ studies

Recommended by international guidelines

Clinical Resources for Healthcare Professionals

Our clinical summaries below demonstrate how plant stanols in VITAPLUS Benecol® can help patients to effectively lower their cholesterol levels.

Clinical Summary 1

A comparison of the LDL-cholesterol lowering efficacy of plant stanols and plant sterols over a continuous dose range: Results of a meta-analysis of randomized, placebo-controlled trials.

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Clinical Summary 2

Effect of a plant stanol ester-containing spread, placebo spread, or Mediterranean diet on estimated cardiovascular risk and lipid, inflammatory and haemostatic factors.

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References

  1. Mach et al. Eur Heart J 2019; 41(1): 111–188.
  2. Piepoli et al. Atherosclerosis 2016; 252: 207–274.
  3. Expert Dyslipidemia Panel of the IAS Panel members. J Clin Lipidol 2014; 8(1): 29–60.
  4. Report of a Joint WHO/FAO Expert Consultation. WHO Technical Report Series 2003; No. 797 – TRS 797.
  5. Lloyd-Jones et al. J Am Coll Cardiol 2017; 70(14): 1785–1822.
  6. Jacobson et al. J Clin Lipidol 2015; 9(2): 129–169.
  7. JBS3 Board. Heart 2014; 100(Suppl 2): ii1–ii67.
  8. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents. Pediatrics 2011; 128(Suppl 5): S213–S256.
  9. Daniels et al. Pediatrics 2008; 122(1): 198–208.
  10. American Diabetes Association. Diabetes Care 2019; 42(Suppl 1): S103–S123.
  11. Evert et al. Diabetes Care 2013; 36(11): 3821–3842.
  12. Brunzell et al. J Am Coll Cardiol 2008; 51(15): 1512–1524.
  13. Wiegman et al. Eur Heart J 2015; 36(36): 2425–2437.
  14. Nordestgaard et al. Eur Heart J 2013; 34(45): 3478–3490.
  15. The EU Register of nutrition and health claims made on foods. EU 2016 [online] available at: https://ec.europa.eu/food/safety/labelling_nutrition/claims/register/public/?event=search (accessed December 2020).
  16. Ostlund et al. Am J Physiol Endocrinol Metab 2002; 282: E911–E916.
  17. Lütjohann et al. J Lipid Res 1993; 34: 1039–1046.
  18. Schiepers et al. J Nutr 2009; 139: 1368–1373.
  19. Berendschot et al. Br J Nutr 2009; 101: 1607–1610.
  20. Kelly et al. Atherosclerosis 2011; 214: 225–230.
  21. Miettinen et al. N Engl J Med 1995; 333(20): 1308–1312.

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