Healthcare Professionals

Benecol® with plant stanol ester – Clinically proven to lower cholesterol

Hypercholesterolemia can be effectively improved with dietary modifications. When guiding patients on a healthy, cholesterol-lowering diet and lifestyle, recommending the use of Plant stanol ester is encouraged by national and international guidelines1–14. Plant stanol ester is the active ingredient in all Benecol® products.

Benecol® is a pioneer in cholesterol-lowering foods. We want to support you in your work as a healthcare professional. This section provides information and materials to help you in your work with hypercholesterolemia patients.

Clinical Resources for Healthcare Professionals

Our clinical summaries below demonstrate how plant stanols in VITAPLUS Benecol® can help patients to effectively lower their cholesterol levels.

Clinical Summary 1

A comparison of the LDL-cholesterol lowering efficacy of plant stanols and plant sterols over a continuous dose range: Results of a meta-analysis of randomized, placebo-controlled trials.

Clinical Summary 2

Effect of a plant stanol ester-containing spread, placebo spread, or Mediterranean diet on estimated cardiovascular risk and lipid, inflammatory and haemostatic factors.


  1. Mach et al. Eur Heart J 2019; 41(1): 111–188.
  2. Piepoli et al. Atherosclerosis 2016; 252: 207–274.
  3. Expert Dyslipidemia Panel of the IAS Panel members. J Clin Lipidol 2014; 8(1): 29–60.
  4. Report of a Joint WHO/FAO Expert Consultation. WHO Technical Report Series 2003; No. 797 – TRS 797.
  5. Lloyd-Jones et al. J Am Coll Cardiol 2017; 70(14): 1785–1822.
  6. Jacobson et al. J Clin Lipidol 2015; 9(2): 129–169.
  7. JBS3 Board. Heart 2014; 100(Suppl 2): ii1–ii67.
  8. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents. Pediatrics 2011; 128(Suppl 5): S213–S256.
  9. Daniels et al. Pediatrics 2008; 122(1): 198–208.
  10. American Diabetes Association. Diabetes Care 2019; 42(Suppl 1): S103–S123.
  11. Evert et al. Diabetes Care 2013; 36(11): 3821–3842.
  12. Brunzell et al. J Am Coll Cardiol 2008; 51(15): 1512–1524.
  13. Wiegman et al. Eur Heart J 2015; 36(36): 2425–2437.
  14. Nordestgaard et al. Eur Heart J 2013; 34(45): 3478–3490.
  15. The EU Register of nutrition and health claims made on foods. EU 2016 [online] available at: (accessed December 2020).
  16. Ostlund et al. Am J Physiol Endocrinol Metab 2002; 282: E911–E916.
  17. Lütjohann et al. J Lipid Res 1993; 34: 1039–1046.
  18. Schiepers et al. J Nutr 2009; 139: 1368–1373.
  19. Berendschot et al. Br J Nutr 2009; 101: 1607–1610.
  20. Kelly et al. Atherosclerosis 2011; 214: 225–230.
  21. Miettinen et al. N Engl J Med 1995; 333(20): 1308–1312.

This content is addressed for healthcare professionals.

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